Kristen Wiig stars as Imogene, once a promising young New York playwright whose promise has fizzled, thanks to a crisis of confidence. Heavily in denial about being dumped by her society boyfriend, Imogene uses her skill for drama to stage an elaborate fake suicide as an appeal for his sympathy. But her attempt backfires when she's put into the custody of Zelda, her estranged gambling addict mother (Annette Bening), and must return home with her to the Jersey shore.

Uptight and straight-laced, FBI Special Agent Sarah Ashburn (Sandra Bullock) is a methodical investigator with a reputation for excellence--and hyper-arrogance. Shannon Mullins (Melissa McCarthy), one of Boston P.D.'s "finest," is foul-mouthed and has a very short fuse, and uses her gut instinct and street smarts to catch the most elusive criminals. Neither has ever had a partner, or a friend for that matter. When these two wildly incompatible law officers join forces to bring down a ruthless drug lord, they become the last thing anyone expected: buddies.